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RECORD NUMBER: 16 OF 38

OLS Field Name OLS Field Data
Main Title Comparison of In vivo and In vitro Methods for Assessing the Effects of Phenobarbital on the Hepatic Drug-Metabolizing Enzyme System.
Author Chadwick, R. W. ; Copeland, M. F. ; Carlson, G. P. ; Trela, B. A. ; Most, B. M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Purdue Univ., Lafayette, IN. School of Pharmacy and Pharmacal Sciences. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/371;
Stock Number PB86-187366
Additional Subjects Phenobarbital ; Toxicology ; Enzymes ; Comparison ; Parenteral infusions ; In viva analysis ; In vitro analysis ; Metabolism ; Rats ; Dosage ; Laboratory animals ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB86-187366 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 14p
Abstract
The effect of daily i.p. injections of 0, 1, 10 and 80 mg/kg phenobarbital for 1 week on the activity of the hepatic drug-metabolizing enzyme system was measured in the rat by a model substrate assay employing lindane and by a battery of in vitro enzyme assays. Comparison of the dose-response curves of the in vivo and in vitro assays indicated that urinary metabolities of indane provided a good index of phenobarbital-induced change in both phase I and phase II reactions.