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RECORD NUMBER: 14 OF 38

OLS Field Name OLS Field Data
Main Title Comparison of In vivo and In vitro Methods for Assessing the Effects of Bromobenzene on the Hepatic-Metabolizing Enzyme System.
Author Chadwick, R. W. ; Copeland, M. F. ; Carlson, G. P. ; Trela, B. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Purdue Univ., Lafayette, IN. School of Pharmacy and Pharmacal Sciences.
Year Published 1987
Report Number EPA/600/J-87/299;
Stock Number PB88-185707
Additional Subjects Bromo organic compounds ; Enzymes ; Liver ; Chlorobenzenes ; Rats ; In vitro analysis ; In vivo analysis ; Reprints ; Bromobenzenes ; Benzene hexachloride ; Lindane
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB88-185707 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/04/1988
Collation 11p
Abstract
The effect of daily i.p. injections of 0, 0.05, 0.5 and 5.0 mmol/kg bromobenzene for 1 week on the activity of the hepatic drug-metabolizing enzyme system was measured in the rat by a model substrate assay employing lindane ( -hexachlorocyclohexane) and by a battery of in vitro enzyme assays. The data in the study indicated that repeated pretreatment with bromobenzene for 1 week stimulated a dose-related increase in phase I reactions while inducing phase II reactions at the high dose (5 mmol/kg bromobenzene). The in vivo and in vitro assays showed good agreement. (Copyright (c) Toxicology Letters, Vol. 39, 1987.)