Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Estimating the potency of mutagens : cytotoxicity as an obligatory consequence of mutagenicity /
Author Carver, June H. ; Branscomb, Elbert W. ; Hatch., Frederick T.
Other Authors
Author Title of a Work
Rausa, G.
Branscomb, Elbert W.
Hatch, Frederick T.
CORP Author California Univ., Livermore. Lawrence Livermore Lab.;Environmental Protection Agency, Washington, DC. Office of Energy, Minerals, and Industry.;Department of Energy, Washington, DC.
Publisher Office of Energy, Minerals and Industry, U.S. Environmental Protection Agency,
Year Published 1979
Report Number EPA/600-7-79-172; UCRL-81690-REV-2; W-7405-ENG-48
Stock Number PB81-152894
OCLC Number 53964402
Additional Subjects Mutagens ; Toxicology ; Bioassay ; Identifying ; Estimating ; Screening ; In vitro analysis ; Hazards ; Cells(Biology) ; Cytotoxicity ; Toxic substances
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD ARCHIVE EPA 600-7-79-172 Headquarters Library/Washington,DC 06/24/2013
EJED  EPA-600/7-79-172 OCSPP Chemical Library/Washington,DC 01/30/2004
EKBD  EPA-600/7-79-172 Research Triangle Park Library/RTP, NC 01/02/2004
ELDD  EPA-600/7-79-172 CCTE/GLTED Library/Duluth,MN 01/28/2005
NTIS  PB81-152894 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 01/01/1988
Collation vii, 11 pages : charts ; 28 cm.
Rapid and reliable screening methods are required for identifying environmental mutagens and estimating their mutagenic potency in preparation for use of more elaborate tests to assess the genetic risk to man. On theoretical grounds, one expects a certain minimum cytotoxic potency to correlate with mutagenic potency, particularly when the latter is measured using forward mutations that result in inactive gene products. Furthermore, as cells cannot divide unless a substantial fraction of their genome is functionally intact, mutagenic agents should also be obligatory cytotoxic agents, with a given mutagenicity conferring a certain irreducible cytotoxicity. The authors show here that the cytotoxic potency of 22 chemical mutagens is highly correlated with their mutagenic potency as assayed in five rodent and human in vitro cell systems. This relationship implies that the maximum potential mutagenic potency of such compounds may be reliably estimated from rapid and straightforward measurements of their cytotoxic potency, the latter defined as the failure of cultured cells to undergo continued cell division. The estimate is necessarily a maximum one, as an agent may exert cytotoxic effects by pathways indpendent of its mutagenic action.
EPA Project Officer: G. Rausa. U.S.D.O.E. Project Director: G. Stapleton. Biomedical Sciences Division, Lawrence Livermore Laboratory, University of California. "August, 1979." Includes bibliographical references (pages 9-11). "EPA/600-7-79-172."