Record Display for the EPA National Library Catalog

RECORD NUMBER: 47 OF 79

OLS Field Name OLS Field Data
Main Title Metabolic interactions of hormonal steroids and chlorinated hydrocarbons : effects of neonatal treatment with o, p'-DDT on the development of the steroidogenic endocrine system of the male rat /
Author Campbell, Kenneth L. ; Campbell, Kenneth L. (Kenneth Lyle), 1948-
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Year Published 1977
Report Number EPA-600-1-77-042; EPA-R-800637
Stock Number PB-272 669
OCLC Number 04122303
Additional Subjects DDT ; Chlorohydrocarbons ; Reproduction(Biology) ; Pesticides ; Steroids ; Endocrine system ; Infants ; Exposure ; Hormones ; Biosynthesis ; Metabolism ; Pituitary hormones ; Pharmacology ; Biochemistry ; Toxicology ; Rats ; Laboratory animals ; Bioassay ; Males ; Injections(Medicine) ; Xenobiotics ; Animal models ; Luteinizing hormone
Internet Access
Description Access URL
http://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=9101F9WO.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
EJAD  EPA 600/1-77-042 Region 3 Library/Philadelphia, PA 11/14/1992
EJBD ARCHIVE EPA 600-1-77-042 Headquarters Library/Washington,DC 06/04/2012
EJBD  EPA 600-1-77-042 c.1 Headquarters Library/Washington,DC 05/27/2014
EKAM  EPA 600/1-77-042 Region 4 Library/Atlanta,GA 01/17/1997
EKDD  EPA 600/1-77-042 NERL/ERD Library/Athens,GA 11/03/2014
NTIS  PB-272 669 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation xvi, 307 pages : illustrations ; 28 cm.
Abstract
The study generated approaches to the measurements of the potential of xenobiotics to alter reproductive capacity and viability which may allow improvement of those currently in use. More specifically, it identified the effects of neonatal exposure to the model compound, o,p'-DDT (1,1,-trichloro-2-(2-chlorophenyl)-2-(4-chlorophenyl)-ethane), on the developing steroidogenic endocrine system of the model animal, the male rat. The effect of exposures by direct injections before day 5 of age and by indirect treatment via an o,p'-DDT injected dam were examined initially by measurement of growth, organ weights, organ histology, and of serum corticosterone and luteinizing hormone (LH). Later experiments included determinations of the effects of o,p'-DDT on the serum LH responses to challenges of the hypothalamo-pituitary axis with adult castration and repeated injections of luteinizing hormone releasing hormone (LHRH). The results are discussed in relation to previous work on steroids and o,p'-DDT in several animal systems, to possible mechanisms, to prospective experiments and to the original goal of the research.
Notes
Environmental health effects research series. Environmental Protection Agency series, EPA 600/1-77-042. Includes bibliographical references (pages 240-260).