Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Metabolic Alterations in the Squirrel Monkey Induced by DDT Administration and Ascorbic Acid Deficiency.
Author Chadwick, R. W. ; Cranmer, M. F. ; Peoples., A. J. ;
CORP Author Environmental Protection Agency, Perrine, Fla. Perrine Primate Lab.
Year Published 1971
Stock Number PB-278 098
Additional Subjects Toxicology ; Pesticides ; Insecticides ; DDT ; Ascorbic acid ; Enzymes ; Metabolism ; Biochemistry ; Nutrition ; Detoxification ; Toxic tolerances ; Nutritional deficiencies ; Monkeys ; Laboratory animals ; Bioassay ; Dosage ; Dose rate ; Reprints ; Glucuronic acid ; Glucaric acid ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB-278 098 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 11p
A daily po injection of 5 mg of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) given to squirrel monkeys for a 2-wk period produces significant increases in liver weight, microsomal protein, cytochrome P-450 and the in vitro activity of various drug metabolizing enzymes. The results indicate that ascorbic acid deficiency may significantly impair both the induction of O-demethylase and the stimulation of the glucuronic acid system by DDT. The D-glucuronic/D-glucaric acid excretion ratio is significantly depressed within 2 days in monkeys fed the ascorbic acid deficient diet. In addition to ascorbic acid deficiency an unknown nutritional factor from the administration of a second lot of the ascorbic acid deficient diet also appears to cause an inhibition of the D-glucuronic/D-glucaric acid excretion ratio. This study provides evidence that interactions between nutritional status and toxic stress may significantly affect some routes of detoxification in the squirrel monkey.