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OLS Field Name OLS Field Data
Main Title 1,2-Dibromoethane Causes Rat Hepatic DNA Damage at Low Doses.
Author Kitchin, K. T. ; Brown, J. L. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/J-86/349;
Stock Number PB87-184685
Additional Subjects Dosage ; Toxicity ; Liver diseases ; Solvents ; Genetics ; Rats ; Carcinogens ; Alpha amino carboxylic acids ; Glutathione ; Cytochromes ; Reprints ; Dibromoethane ; Halogenated hydrocarbons ; Mutagens ; SGPT(Serum Alanine Transaminase)
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Status
NTIS  PB87-184685 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 8p
Abstract
Two oral administrations of 1,2-dibromoethane to adult female rats at doses above 10 micromoles/kg (1.9 mg/kg) caused DNA damage as determined by the alkaline elution technique. Far greater doses (300 micromoles/kg, 56.4 mg/kg) of 1,2-dibromoethane were required to cause other hepatic biochemical effects, such as increased activity of ornithine decarboxylase. In the dose range of 10-300 micromoles/kg, no increase in the activity of serum enzyme alanine transaminase (SGPT) was observed. Of the six organs studied, liver showed the largest amount of DNA damage. Thus, the carcinogen 1,2-dibromoethane caused substantial DNA damage at doses far below those required to show other biochemical effects or frank liver toxicity.