||Genotoxicity Studies of Benz(1)Aceanthrylene.
Kligerman, A. D. ;
Moore, M. M. ;
Erexson, G. L. ;
Brock, K. H. ;
Doerr, C. L. ;
||Environmental Health Research and Testing, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Aromatic polycyclic hydrocarbons ;
Toxic substances ;
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The genotoxicity of the cyclopenta-fused polycyclic aromatic hydrocarbon, benz(1)aceanthrylene (B(1)A),was evaluated in vitro using the L5178Y/T (K sup +/-) mouse lymphoma assay and in vivo using the mouse peripheral blood lymphocyte (PBL) culture system. The mutagenicity and sister chromatid exchange (SCE) inducing potential of B(1)A) was then compared to that of benzo(a)pyrene (B(a)P). B(1)A appeared to be slightly less mutagenic than B(a)P at the TK locus, and each compound produced both small and large colony mutants indicating that they are clastogenic as well as mutagenic. Gross chromosome aberration analysis of treated L5178Y/TK+/- mouse lymphoma cells confirmed the clastogenicity of B(1)A in vitro. In the mouse PBL system, after administration by gavage, B(1)A was more cytoxic nd produced a sharper elevation in SCE frequency than B(a)P. (Copyright (c) Cancer Letters, 1986.)