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RECORD NUMBER: 3 OF 3

OLS Field Name OLS Field Data
Main Title Manual for the Microscopic Diagnosis of Proliferative Liver and Skin Lesions in the Brown Bullhead (Ameiurus nebulosus).
Author V. S. Blazer ; J. W. Fournie ; J. C. Wolf ; M. J. Wolfe
CORP Author National Fish Health Research Lab., Kearneysville, WV.; National Health and Environmental Effects Research Lab., Gulf Breeze, LA. Gulf Ecology Div.; Experimental Pathology Laboratories, Inc., Sterling, VA.; Geological Survey, Reston, VA.; Pennsylvania State Univ., Erie. Sea Grant Program.
Year Published 2007
Stock Number PB2012-100933
Additional Subjects Liver ; Skin ; Neoplasms ; Fishes ; Diagnosis ; Histology ; Lesions ; Contaminants ; Cells(Biology) ; Carcinoma ; Melanoma ; Water pollution control ; Fresh water ; Manuals ; Surveys ; Brown bullhead ; Ameiurus nebulosus
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB2012-100933 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/29/2012
Collation 38p
Abstract
Over the years numerous surveys have been undertaken to assess the incidence of skin and liver tumors, as well as other contaminant-associated microscopic lesions at areas of concerns (AOCs). However, a major problem is a lack of consistent criteria for evaluating microscopic (histological) changes in bullhead liver and skin. For instance, in some studies there is no distinction between preneoplastic (altered foci) and neoplastic lesions, or no good descriptions of individual lesions (Black 1983; Pyron et al. 2001). Some studies included only carcinomas as neoplasia, while in others adenomas, carcinomas, and cholangiomas were included (Baumann et al. 2000) and some included carcinomas, adenomas and altered foci (Maccubbin and Ersing 1991). Skin tumors are often diagnosed visually without the supporting histological verification. Hence, standardization of the criteria being used to evaluate the impairment is necessary, so that data from different years, reference sites and Areas of Concern can be adequately compared.