||Carcinogenicity of Benzo(a)pyrene in Rainbow Trout Resulting from Embryo Microinjection.
Black, J. J. ;
Maccubbin, A. E. ;
Johnston, C. J. ;
||Roswell Park Memorial Inst., Buffalo, NY. Dept. of Experimental Biology.;Environmental Research Lab.-Duluth, MN.
Liver neoplasms ;
Salmo gairdneri ;
Carcinogenicity tests ;
Water pollution effects(Animals) ;
Dose-response relationships ;
High pressure liquid chromatography
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Rainbow trout (Salmo gairdneri) embryos were exposed in ovo to benzo(a)pyrene (BaP) by a single transchorionic injection. Injected BaP was retained in the yolk sac of larval trout and was only slowly metabolized until swim-up. One year post-exposure, BaP-treated fish had an elevated incidence of liver neoplasms which ranged from small basophilic microfoci of altered hepatocytes to large hepatocellular carcinomas. These results demonstrate carcinogenesis in rainbow trout from single dose exposure to BaP, a widely distributed environmental pollutant that has been implicated as the cause of liver neoplasia in wild fish and some human cancers. (Copyright (c) 1988 Elsevier Science Publishers B.V.)