Record Display for the EPA National Library Catalog

RECORD NUMBER: 48 OF 50

OLS Field Name OLS Field Data
Main Title Synergistic effect of polonium-210 and cigarette smoke in rats /
Author Black, Stuart C., ; Bretthauer., E. W.
CORP Author National Environmental Research Center, Las Vegas, Nev. Monitoring Systems Research and Development Lab.
Publisher National Environmental Research Center,
Year Published 1975
Report Number EPA-680/1-75-001; ROAP 21AMC; 1FA082
Stock Number PB-246 174
OCLC Number 01986430
Subjects Polonium--Physiological aspects. ; Lungs--Cancer. ; Lung Neoplasms--etiology. ; Neoplasms, Experimental.
Additional Subjects Polonium 210 ; Smoking ; Radiation effects ; Radioactive isotopes ; Rats ; Laboratory animals ; Experimental data ; Exposure ; Lung ; Neoplasms ; Respiratory diseases ; Bronchitis ; Pathology ; Cigarette smoking ; Synergistic effects of air pollution ; Carcinogenesis
Internet Access
Description Access URL
https://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=9101VUOJ.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
EIAD  EPA-680/1-75-001 Region 2 Library/New York,NY 03/18/2005 DISPERSAL
EJBD ARCHIVE EPA 680-1-75-001 Headquarters Library/Washington,DC 05/28/2013
EJBD  EPA 680-1-75-001 Headquarters Library/Washington,DC 06/10/2015
EKAM  EPA-680/1-75-001 Region 4 Library/Atlanta,GA 12/31/1998
EKBD  EPA-680/1-75-001 Research Triangle Park Library/RTP, NC 09/09/2016
NTIS  PB-246 174 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 01/01/1988
Collation v, 12 pages : illustrations ; 27 cm
Abstract
An experimental procedure was devised to test the possible synergistic effect of polonium-210 and cigarette smoke in rats. Appropriate techniques were developed to expose the rats to cigarette smoke through mouth-breathing and to add known amounts of polonium-210 to the cigarette smoke. The findings from this experiment included: (1) lung deposition of polonium-210 was 31 plus or minus 2%, (2) early retention of polonium was two-phased with half-times of 4 and 84 hours, and (3) bronchitis, emphysema and lung tumors were observed in the experimental animals. Though the spontaneous occurrence of two lung tumors in the number of animals at risk was highly improbable, any conclusion that this resulted from the exposure to cigarette smoke must be highly qualified.
Notes
ROAP 21AMC Program element 1FA082. Includes bibliographical references (pages 11-12).