||Chlorinated Insecticides and Related Materials in Human Urine.
Cueto, Jr., Cipriano ;
Biros., Francis J. ;
||National Communicable Disease Center, Atlanta, Ga.
Chemical analysis ;
Gas chromatography ;
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A new gas chromatographic method for the analysis of chlorinated hydrocarbon insecticides and their neutral metabolites in human urine is presented. Good reproducibility and recovery are obtained. In the majority of trials, recovery was 80% or better. The method was applied to urine specimens from men and women of the general population and has resulted in the detection of ten isomers or metabolites of chlorinated hydrocarbon insecticides. The excretion of these materials in the urine of individuals with no occupational exposure to chlorinated insecticides has not been detected previously. It is undoubtedly the extremely high sensitivity of the electron-capture detector to chlorinated hydrocarbon insecticides and the good reproducibility of measurements made in this way that make it possible to establish the excretion levels demonstrated in this work.