||Controlled Clinical Evaluations of Chlorine Dioxide, Chlorite and Chlorate in Man.
Lubbers, Judith R. ;
Chauan, Sudha ;
Bianchine, Joseph R. ;
||Ohio State Univ., Columbus. Coll. of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Chlorine dioxide ;
Physiological effects ;
Water pollution effects(Humans)
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
To assess the relative safety of chronically administered chlorine water disinfectants in man, a controlled study was undertaken. The clinical evaluation was conducted in the three phases common to investigational drug studies. Phase I, a rising does tolerance investigation, examined the acute effects of progressively increasing single doses of chlorine disinfectants to normal healthy adult male volunteers. Phase II considered the impact on normal subjects of daily ingestion of the disinfectants at a concentration of 5mg/l. for twelve consecutive weeks. Persons with a low level of glucose-6-phosphate dehydrogenase may be expected to be especially susceptible to oxidative stress; therefore, in Phase III, chlorite at a concentration of 5mg/l. was administered daily for twelve consecutive weeks to a small group of potentially at-risk glucose-6-phosphate dehydrogenase-deficient subjects.