Record Display for the EPA National Library Catalog

RECORD NUMBER: 19 OF 23

OLS Field Name OLS Field Data
Main Title Serum Organochlorine Pesticides in Mentally Retarded Patients on Differing Drug Regimens.
Author Watson, Michael ; Gabica, Joe ; Benson., W. W. ;
CORP Author Idaho State Dept. of Health, Boise.
Year Published 1971
Stock Number PB-279 747
Additional Subjects Pesticides ; DDT ; Toxicology ; Tranquilizer drugs ; Anticonvulsants ; Patients ; Gas chromatography ; Drug therapy ; Chlorine organic compounds ; Tables(Data) ; Experimental data ; Drugs ; Metabolism ; Pharmacology ; Blood chemical analysis ; Chemotherapy ; Reprints ; Mentally retarded persons ; DDE insecticide ; Metabolites ; Toxic substances ; Bioaccumulation
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB-279 747 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 8p
Abstract
Serum concentrations of p,p'DDT and its metabolite p,p'DDE were estimated by electron-capture gas chromatography in a group of mentally retarded institutionalized patients receiving antiseizure and tranquilizing chemotherapy. Control patients not taking drugs tended to resemble the general population in terms of organochlorine residues, but drug takers showed greatly lowered levels of both p,p'DDE and p,p'DDT. The combination of phenobarbital and diphenylhydantoin seemed to be the most effective in depressing serum pesticides and remained so even in patients taking other drugs concurrently. P,P'DDE was found at detectable levels in all patients sampled, but the frequency of occurrence of p,p'DDT was considerably decreased among the drug takers. This was particularly true of patients receiving both phenobarbital and diphenylhydantoin concurrently. The possibility that the catabolism of p,p'DDT is induced preferentially to that of p,p'DDE by the phenobarbital-diphenylhydantoin combination is discussed.