Record Display for the EPA National Library Catalog
RECORD NUMBER: 15 OF 15
|OLS Field Name||OLS Field Data|
|Main Title||Toluene Levels in Blood and Brain of Rats during and after Respiratory Exposure.|
|Author||Benignus, Vernon A. ; Muller, Keith E. ; Barton, Curtis N. ; Brittikofer, John A. ;|
|CORP Author||North Carolina Univ. at Chapel Hill.;Health Effects Research Lab., Research Triangle Park, NC.|
|Additional Subjects||Toluene ; Bioassay ; Rats ; Laboratory animals ; Blood analysis ; Brain ; Reprints ; Air pollution effects(Animals)|
Eighty rats were exposed to 575 ppm toluene by inhalation for up to 240 min. Animals in one group were sacrificed during exposure at 15, 30, 60, 120, or 240 min. Following a 240-min exposure, groups of rats were sacrificed at 15, 30, 120, or 240 min. Blood was drawn from the vena cava of sacrified subjects. Brains were extracted and homogenized. Blood and brain tissue were assayed for toluene by gas chromatography. One-compartment pharmacokinetic models were fitted to predict toluene levels in blood and whole brain as a function of time.