Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effects of Low to Moderate Lead Exposure on Slow Cortical Potentials in Young Children: Two Year Follow-Up Study (Journal Version).
Author Otto, D. ; Benignus, V. ; Muller, K. ; Barton, C. ; Seiple, K. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1982
Report Number EPA-600/J-82-321;
Stock Number PB83-219642
Additional Subjects Lead(Metal) ; Toxicology ; Children ; Humans ; Exposure ; Reprints ; Neurotoxicity
Library Call Number Additional Info Location Last
NTIS  PB83-219642 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 7p
A follow-up study of slow cortical potentials in children with elevated blood lead (PbB) histories was conducted two years after initial evaluation. An age x PbB interaction was again observed wherein slow wave (SW) voltage varied as a linear function of PbB with the slope of the function dependent on age. The linear relationship of SW voltage and PbB was significant using either original PbB values, (14-55 microgram/dl), follow-up values (11-39 microgram/dl), or the mean of the two PbB values. No evidence of a threshold for this effort was observed. The similarity of results obtained at initial and follow-up assessments suggests that the observed alterations in CNS function are persistent, despite a significant decrease in mean PbB across time. The observed change in SW voltage at PbB levels previously considered to be harmless suggests the need to reconsider the currently accepted 30 microgram/dl threshold for undue lead absorption in children.