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OLS Field Name OLS Field Data
Main Title Alpha-2u-globulin : association with chemically induced renal toxicity and neoplasia in the male rat /
Author Baetcke, K. P. ; Hard, G. C. ; Rodgers, I. S. ; McGaughy, R. E. ; Tahan, L. M.
Other Authors
Author Title of a Work
Baetcke, Karl.
CORP Author Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher U.S. Environmental Protection Agency,
Year Published 1991
Report Number EPA/625/3-91/019F; OHEA-F-385
Stock Number PB92-143668
Subjects Risk assessment. ; Alpha globulins.
Additional Subjects Toxicity ; Kidney ; Kidney neoplasms ; Rats ; Carcinogens ; Males ; Risk assessment ; Kidney diseases ; Dose-response relationships ; Species specificity ; Alpha 2-microglobulins
Internet Access
Description Access URL
http://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=3000480X.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB92-143668 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation 132 pages ; 28 cm
Abstract
The report of a Technical Panel of the U.S. Environmental Protection Agency (EPA) Risk Assessment Forum describes conditions under which the Forum advises EPA risk assessors against using information on certain renal tubule tumors or nephrotoxicity to assess human risk. Risk assessment approaches generally assume that chemicals producing tumors in laboratory animals are a potential cancer hazard to humans. For most chemicals, including many rodent kidney carcinogens, this extrapolation remains appropriate. The scientific studies reviewed by the Technical Panel indicate, however, that some other chemicals induce accumulation of alpha(sub 2u)-globulin, a low-molecular-weight protein, in the male rat kidney. Female rats and other laboratory mammals administered the same chemicals do not accumulate low-molecular-weight protein in the kidney and they do not develop renal tubule tumors. Since humans appear to be more like other laboratory animals than like the male rat, in this special situation, the male rat is not a good model for assessing human risk.
Notes
"Risk Assessment Forum." "EPA/625/3-91/019F." "September 1991." Microfiche.