Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effect of Ambient Temperature and Running Wheel Activity on the Outcome of Pregnancy in CD-1 Mice.
Author Berman, E. ; House, D. ; Carter, H. B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Developmental Toxicology Div.
Publisher c6 Jun 89
Year Published 1989
Report Number EPA/600/J-90/125;
Stock Number PB91-109645
Additional Subjects Mathematical models ; Embryos ; Exercise(Physiology) ; Laboratory animals ; Mice ; Body temperature ; Infrared radiation ; Reprints ; Atmospheric temperature ; Embryotoxins
Library Call Number Additional Info Location Last
NTIS  PB91-109645 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/04/1991
Collation 12p
The effect of ambient temperature T(sub a) and running wheel activity (RWA) on fetal outcome was studied in CD-1 mice. Pregnant mice were allowed to be active in a running wheel at various T(sub a)'s (26, 30, 32, 34 or 36C) for 100 mins a day. The dams were killed near term, and various maternal and fetal measurements made. Mean deep body temperature T(sub b) in pregnant dams while running (measured using radio-telethermometers implanted in the abdomen) was raised to 39.5 C at T(sub a)=36. Bred mice continued to increase their RWA, pregnant or not, but pregnant mice exercise less from mid-pregnancy on. RWA up to 1 km/hr had no effect on maternal weight gain, litter size, number of live fetuses, fetal body weight and fetal relative brain weight. However, increasing T(sub a) was effective in decreasing maternal weight gain and fetal body weight, and increasing fetal relative brain weight. Even though T(sub b) can be increased significantly by either RWA or T(sub a), the increase caused by RWA appears to have no significant influence on the outcome of pregnancy. At levels in this study, T(sub b) per se does not appear to be the variable on which to predict fetal effects. This is because only T(sub b) from T(sub a), and not T(sub b) from RWA, could be shown to effect a fetal change. (Copyright (c) 1990 Wiley-Liss, Inc.).