Record Display for the EPA National Library Catalog
RECORD NUMBER: 5 OF 15
|OLS Field Name||OLS Field Data|
|Main Title||Effects of atmospheric mix and toxic fumes on military performance /|
|Author||Benignus, Vernon A.|
|CORP Author||Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.|
|Publisher||U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,|
|Additional Subjects||Carbon dioxide ; Carbon monoxide ; Hydrogen cyanide ; Hypoxia ; Toxicity ; Exposure ; Mathematical models ; Combustion products ; Lethal dosage ; Weapon systems ; Air pollution effects(Humans) ; Pharmacokinetics|
|Collation||85 pages ; 28 cm|
The present chapter covers the individual and combined neurobehavioral effects of carbon monoxide, hydrogen cyanide, carbon dioxide and hypoxic hypoxia. The effects of each were reviewed separately and then the literature of the effects of combined exposures were covered. The latter is a relatively sparse literature. The empirical and physiological information available was encoded as a series of dose-effects and pharmacokinetic equations. Assuming additive effects, a mathematical model was proposed for the combined exposure. Several pharmacokinetic interactions make the received dose of the combined pollutants nonadditive, however, and thus introduce nonadditivity into the combined model. The model was useful in pointing out the kind of information still needed to make predictions. The model thus serves a mainly heuristic purpose.
EPA/600/D-89/060. PB89-223630. Microfiche.