||Effects of Age and Body Lead Burden on CNS Function in Young Children. I. Slow Cortical Potentials.
Otto, D. A. ;
Benignus, V. A. ;
Muller, K. E. ;
Barton, C. N. ;
||North Carolina Univ. at Chapel Hill.;Health Effects Research Lab., Research Triangle Park, NC.
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The effects of body Pb burden on slow cortical potentials were studied in 63 children aged 13-75 months. Slow wave (SW) voltage during sensory conditioning varied as a linear function of blood lead (PbB) level. The slope of this fuction, moreover, changed systematically with age. For children under 5 years of age, SW voltage tended to be positive at low PbBs and to be negative above 30 micrograms/d1. For children over 5 years of age, SW voltage tended to be negative at low PbBs and to be less negative (or positive) above 30 micrograms/d1. These results provide evidence of altered CNS function at the lowest Pb effect level ever reported.