||Activation of Aromatic Amines to Mutagens by Bovine Bladder and Liver Cells.
Oglesby, Linda ;
Hix-Baker, Cathy ;
MacNair, Pat ;
Sieg, Marianne ;
Snow, Linda ;
||Health Effects Research Lab., Research Triangle Park, NC.
Aromatic compounds ;
Laboratory animals ;
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A bovine bladder cell-mediated mutagenesis system using Chinese hamster V79 cells and Samonella typhimurium as target organisms was developed to investigate the capacity of the bladder urothelium to activate chemical carcinogens. Bovine bladder epithelial cells can activate the aromatic amines AF and 4-ABP to intermediates which mutate V79 cells and S. typhimurium TA 98 and TA 100. DMBA was mutagenic to V79 cells but not detectably mutagenic to either Salmonella strain with bladder cell activation. The chemicals tested were not mutagenic to either target organism in the absence of bladder cells.