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RECORD NUMBER: 21 OF 40

OLS Field Name OLS Field Data
Main Title Influence of Sediment Extract Fractionation Methods on Bioassay Results.
Author Ho, K. T. ; Mills, L. J. ; Mueller, C. ; Anderson, S. C. ; Malcolm, A. R. ;
CORP Author Rhode Island Univ., Narragansett. Graduate School of Oceanography. ;Science Applications International Corp., Narragansett, RI.;Environmental Research Lab., Narragansett, RI.
Publisher c1994
Year Published 1994
Report Number EPA-68-C1-0005, EPA-R-815992; EPA/600/J-94/481 ; ERLN-1441
Stock Number PB95-136859
Additional Subjects Toxicity ; Sediments ; Bioassay ; Water quality ; Mutations ; Sister chromatid exchange ; Genetic effects ; Comparative evaluation ; Biotechnology ; Reprints ; Extract fractionation ; Microtox ; Mutatox ; Metabolic cooperation
Holdings
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Status
NTIS  PB95-136859 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/06/1995
Collation 11p
Abstract
Four bioassays (Microtox, Mutatox, sister chromatid exchange (SCE), and metabolic cooperation) were used to analyze marine sediment extracts fractionated by two different methods: silica gel column chromatography and acid-based fractionation. Results indicated that a sediment extract fractionated with different methods can lead to different conclusions about the same sediment. This research also further evaluated the new, mutagenic, bacterial bioassay Mutatox. Mutatox generally correlated with SCE and the Salmonella typhimurium assays. This rapid, operationally simple bioassay has potential as a screening bioassay to detect genotoxic agents. (Copyright (c) 1994 John Wiley & Sons, Inc.)