||Health assessment document for trichloroethylene.
Anderson, L. D. ;
Bayard, S. ;
Benignus, V. ;
Chen, C. W. ;
Fowle, J. R.
||Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
|| U.S. Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office,
Trichloroethane--Toxicology--United States. ;
Air--Pollution--Physiological effect--United States. ;
Air--Pollution--United States--Physiological effect
Industrial hygiene ;
Air pollution ;
Laboratory animals ;
Malignant neoplasms ;
Urban areas ;
Occupational safety and health ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||378 pages : illustrations ; 28 cm
Trichloroethylene (TCI) is a solvent widely used in the industrial degreasing of metals. It has been detected in the ambient air of a variety of urban and non-urban areas of the United States and also, in natural and municipal waters. The weight of available evidence obtained from both animal and human data suggest that long-term exposure to environmental levels of TCI poses no serious health concern to the general population. No teratogenic potential has been demonstrated for TCI in studies conducted to date with experimental animals. With respect to the mutagenic potential of TCI, the data on pure TCI do not allow a conclusion to be drawn. If TCI is mutagenic, the available data suggest it would be a very weak, indirect mutagen. Based on available animal data, there is sufficient animal evidence for carcinogenicity. Based on the Agency's Proposed Guidelines for Carcinogen Assessment, the overall evidence for TCI would result in a classification of B2, i.e., a probable human carcinogen.
"Final report." "July 1985." Includes bibliographical references. "EPA-600/8-82-006F." Microfiche.