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RECORD NUMBER: 2 OF 15

OLS Field Name OLS Field Data
Main Title Acute Elevation of Blood Carboxyhemoglobin to 6% Impairs Exercise Performance and Aggravates Symptoms in Patients with Ischemic Heart Disease (Journal Version).
Author Adams, K. F. ; Koch, G. ; Chatterjee, B. ; Goldstein, G. M. ; O'Neil, J. J. ;
CORP Author North Carolina Univ. at Chapel Hill.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1988
Year Published 1988
Report Number EPA/600/J-88/267;
Stock Number PB89-144687
Additional Subjects Carbon monoxide ; Coronary artery disease ; Exercise(Physiology) ; Aortic insufficiency ; Ischemia ; Tables(Data) ; Heart function tests ; Toxicity ; Angina pectoris ; Exposure ; Reprints ; Carboxyhemoglobin ; Air pollution effects(Humous) ; Ventricular outflow obstruction
Holdings
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Status
NTIS  PB89-144687 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/08/1989
Collation 12p
Abstract
Acute exposure to carbon monoxide has the potential to impair exercise capacity in patients with ischemic heart disease. We studied the effect of inhalation of this compound sufficient to gradually produce a level of 6% carboxyhemoglobin in 30 non-smoking patients with obstructive coronary artery disease and evidence of exercise induced ischemia. On the carbon monoxide day, mean post exposure carboxyhemoglobin was 5.9 + or - 1% compared to 1.6 + or - 0.1% (p is less than .01) after air exposure. The results demonstrate earlier onset of ventricular dysfunction, angina, and poorer exercise performance in patients with ischemic heart disease after acute carbon monoxide exposure sufficient to increase carboxyhemoglobin to 6%. (Copyright (c) 1988 By the American College of Cardiology.)