||Armitage-Doll Two-Stage Model: Implications and Extension.
Chen, C. W. ;
||Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Risk assessment ;
Mathematical models ;
MVK model ;
Two-stage models ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The objective of the paper is twofold: (1) to provide insight on the simplified MVK model of carcinogenesis by revealing the relationship between the Armitage-Doll two-stage model (ADT model) and the simplified MVK model; and (2) to extend the ADT model to one with time-varying (piece-wise constant) parameters. It is shown that the simplified MVK model is a special case of the Armitage-Doll two-stage model , and many applications of the simplified MVK model involving intermittent exposures or exposures to different compounds in different time periods can be derived easily from the ADT model with piece-wise constant parameters. The limitations of the ADT model are discussed. (Copyright (c) 1993 Society for Risk Analysis.)