Record Display for the EPA National Library Catalog
RECORD NUMBER: 616 OF 2096| Main Title | Initial Submission: Acute Oral Toxicity of 1,2,4-benzen Tricarboxylic Acid, Trimethyl Ester in Rats with Cover Letter dated 08/29/92. | |||||||||||
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| CORP Author | Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. | |||||||||||
| Year Published | 1992 | |||||||||||
| Report Number | 88-920008903 | |||||||||||
| Stock Number | OTS0570948 | |||||||||||
| Additional Subjects | Toxicology ; Health effects ; 1 ; 2 ; 4-benzen Tricarboxylic Acid ; Trimethyl Ester ; Acute Toxicity ; Mammals ; Rats ; Oral ; Gavage ; Toxic substances ; Laboratory animals ; CAS No 2459-10-1 | |||||||||||
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| Collation | 13p | |||||||||||
| Abstract | Trimethyl 1,2,4-benzenetricarboxylate (CAS No. 2459-10-1) was evaluated for acute oral toxicity. The test substance was administered by intragastric intubation to young adult ChR-CD male rats. Dosage levels and mortality data are as follows: 10,000 (0/10); 11,000 (4/10); 12,000 (4/10); and 14,000 mg/kg of body weight (8/10), with all deaths occurring 4-days after dosing. Clinical signs at 10,000 mg/kg and above included salivation, weakness, stained and wet perineal area, stained face, pallor, chromodacryorrhea, and moderate weight loss. The LD50 was determined to be 12,232 mg/kg b.w. |