Basic Physiology and Pharmacology -- Physiology and Pharmacology of the GABA System: Focus on GABA Receptors -- Development of Subtype-Selective GABAA Receptor Compounds for the Treatment of Anxiety, Sleep Disorders and Epilepsy -- Distribution of GABAA Receptor Subunits in the Human Brain -- Pharmacokinetic Determinants of the Clinical Effects of Benzodiazepine Agonist Hypnotics -- Sleep Science and Circuitry -- Sleep and Its Modulation by Substances That Affect GABAA Receptor Function -- Subcortical Neuromodulation of Feedforward and Feedback Inhibitory Microcircuits by the Reticular Activating System -- Function of GABAB and ?-Containing GABAA Receptors (GABAC Receptors) in the Regulation of Basic and Higher Integrated Sleep-Waking Processes -- Interactions Between GABAergic and Serotonergic Processes in the Dorsal Raphe Nucleus in the Control of REM Sleep and Wakefulness -- GABA-ergic Modulation of Pontine Cholinergic and Noradrenergic Neurons for REM Sleep Generation -- Involvement of GABAergic Mechanisms in the Laterodorsal and Pedunculopontine Tegmental Nuclei (LDT-PPT) in the Promotion of REM Sleep -- GABAergic Mechanisms in the Ventral Oral Pontine Tegmentum: The REM Sleep-Induction Site - in the Modulation of Sleep-Wake States -- The Role of GABAergic Modulation of Mesopontine Cholinergic Neurotransmission in Rapid Eye Movement (REM) Sleep -- Melatonin and Sleep: Possible Involvement of GABAergic Mechanisms -- GABA Involvement in the Circadian Regulation of Sleep -- Hypnotics -- Pathophysiology of Sleep Disorders -- Insomnia: Differential Diagnosis and Current Treatment Approach -- Zolpidem in the Treatment of Adult and Elderly Primary Insomnia Patients -- Efficacy and Safety of Zopiclone and Eszopiclone in the Treatment of Primary and Comorbid Insomnia -- Indiplon -- Polysomnographic and Clinical Assessment of Zaleplon for the Treatment of Primary Insomnia. GABA (gamma-aminobutyric acid) is the main neurotransmitter regulating sleep. The majority of drugs presently in use for the treatment of sleep disorders act by enhancing GABAergic neuronal inhibition. This book brings together many of the world's leading investigators to discuss current and anticipated developments in the areas of geriatric sleep medicine and provides a comprehensive examination of current principles and practice in this field. It is divided into three main sections: Section I: Basic Physiology and Pharmacology Section II: Sleep Science and Circuitry Section III: Neurotherapeutics The areas covered include findings from research investigations various aspects of GABAergic systems and the regulation of sleep. The book is suitable for basic and clinical neuropharmacologists, sleep researchers, psychiatrists, sleep disorders specialists, clinicians, medical students, and all professionals interested in the interdisciplinary areas of sleep and neuropharmacology.