Record Display for the EPA National Library Catalog
RECORD NUMBER: 18 OF 3696| Main Title | 7,12-Dimethylbenz(a)anthracene-Deoxyribonucleoside Adduct Formation 'in vivo': Evidence for the Formation and Binding of a Monohydroxymethyl-DMBA (Dimethylbenz(a)anthracene) Metabolite to Rat Liver DNA (Deoxyribonucleic Acid). | |||||||||||
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| Author | Joyce, N. J. ; Daniel, F. B. ; | |||||||||||
| CORP Author | Health Effects Research Lab., Research Triangle Park, NC. | |||||||||||
| Year Published | 1982 | |||||||||||
| Report Number | EPA-600/J-82-275; | |||||||||||
| Stock Number | PB83-163477 | |||||||||||
| Additional Subjects | Carcinogens ; Deoxyribonucleic acids ; Rats ; Liver ; Deoxyribonucleic acids ; Parenteral infusions ; Chemical analysis ; Fluorescence ; Aromatic polycyclic hydrocarbons ; Malignant neoplasms ; Reprints ; Benzanthracene/dimethyl ; Benzanthracene/hydroxymethyl-dimethyl ; High performance liquid chromatography ; Cancer | |||||||||||
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| Collation | 7p | |||||||||||
| Abstract | The polycyclic aromatic hydrocarbon, 7,12-dimethyl benz(a)anthracene (DMBA) is a potent carcinogen to the female Sprague-Dawley rat, and when administered under conditions that have been shown to produce cancer, results in extensive formation of hydrocarbon-deoxyribonucleoside adducts. Sephadex LH-20 and reverse-phase h.p.l.c. and spectrofluorometric analysis of these adducts demonstrate that at least one adduct results from the binding of 7,12-dimethylbenz(a)anthracene-1,2,3,4-tetrahydro-3,4-dihydroxy-1,2-oxide. |