Record Display for the EPA National Library Catalog


Main Title Serological Responses among Teenagers after Natural Exposure to Norwalk Virus.
Author Baron, R. C. ; Greenberg, H. B. ; Cukor, G. ; Blacklow, N. R. ;
CORP Author Massachusetts Univ. Medical School, Worcester.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA/600/J-84/167;
Stock Number PB85-151314
Additional Subjects Serology ; Viruses ; Youths ; Immunity ; Antibodies ; Infectious diseases ; Reprints ; Norwalk virus
Library Call Number Additional Info Location Last
NTIS  PB85-151314 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 6p
Twenty-one teenagers who were exposed to the common source during an outbreak of gastroenteritis were tested for seroconversion to the Norwalk virus. Serum pairs were collected within 72 hours of exposure and four weeks later. Each of the 11 subjects who developed symptoms and five persons who remained well demonstrated a whole serum antibody response, while five non-ill subjects failed to seroconvert. The absence of detectable antibody in the acute-phase serum specimens was not statistically associated with subsequent seroconversion or susceptibility to illness. These findings underscore the view that immunity to this agent is not determined by serum antibody and support the concept that susceptibility may be determined by Norwalk-specific intestinal receptor sites.