Record Display for the EPA National Library Catalog


Main Title Pulmonary Function Effects of 1.0 and 2.0 ppm Sulfur Dioxide Exposure in Active Young Male Non-Smokers.
Author Bedi, J. F. ; Folinsbee, L. J. ; Horvath, S. M. ;
CORP Author California Univ., Santa Barbara. Inst. of Environmental Stress.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA-R-807890; EPA/600/J-84/280;
Stock Number PB85-193670
Additional Subjects Sulfur dioxide ; Air pollution ; Toxicology ; Exposure ; Exercise(physiology) ; Reprints ; Spirometry ; Respiratory function tests ; Health risks ; Youths ; Males ; Non smokers
Library Call Number Additional Info Location Last
NTIS  PB85-193670 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 6p
The threshold concentration of sulfur dioxide which will induce pulmonary function changes in the normal population has not been established. To investigate this question, the authors exposed nine young healthy adult non-smoking males for 2 hours to filtered air (FA), 1.0 ppm sulfur dioxide and 2.0 ppm sulfur dioxide. In a follow-up study an additional fourteen subjects were exposed to FA and 1.0 ppm sulfur dioxide conditions. Forced expiratory tests were performed prior to and following the 2 h exposure, and 5 min after each of the three 30 minute exercise periods. The work load during the exercise periods was set to elicit a minute ventilation of 40 liter BTPS. Thoracic Gas Volume (TGV), Airway Resistance (Raw), Maximal Voluntary. Ventilation (MVV) and helium dilution Functional Residual Capacity (FRC) were also measured before and after the exposure. In the initial subject group (n=9), none of the spirometric tests demonstrated any significant effects to the subject from exposure to 1.0 or 2.0 ppm of SO2 either after 30 minutes of continuous exercise or 2 hours of intermittent exercise. The only significant change (p<.05) was an increase in specific airway resistance (SRaw) following exposure to 1.0 or 2.0 ppm sulfur dioxide. However, when this observation was further studied in the larger (n=23) subject group exposed to 1.0 ppm SO2, neither SRaw nor any of the other pulmonary function test indicated a significant effect of exposure to 1.0 ppm sulfur dioxide. (Copyright (c) 1984, Air Pollution Control Association.)