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RECORD NUMBER: 35 OF 99

OLS Field Name OLS Field Data
Main Title Initial Submission: Teratogenicity Study with Xylene in Mice with Cover Letter dated 07/22/92.
CORP Author Research Triangle Inst., Research Triangle Park, NC.; Rohm and Haas Co., Philadelphia, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 88-920005518
Stock Number OTS0544772
Additional Subjects Toxicology ; Health effects ; Xylene ; Reproduction/fertility Effects ; Teratogenicity ; Mammals ; Mice ; Toxic substances ; Laboratory animals ; CAS No 1330-20-7
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NTIS  OTS0544772 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 62p
Abstract
Xylene (CAS No. 1330-207) was evaluated for developmental effects in mice administered the test substance by gavage at dose levels of 0, 0.6, 1.2, 2.4, 3.0, 3.6 or 4.2 mL/kg/day. There were 15/15 mortalities at 4.2 mL/kg/day and 12/38 at 3.6 mL/kg/day. Maternal body weight gain was reduced in survivors at 3.6 mL/kg/day (p<0.05). The average maternal liver weight was increased at 2.4 and 3.0 mL/kg/day and the average fetal weight was reduced at 2.4 and 3.0 mL/kg/day (p<0.05). The average percent of malformed fetuses was increased at 2.4, 3.0, and 3.6 mL/kg/day (p<0.01). Cleft palate was observed in the 1.2, 2.4, 3.0, and 3.6 mL/kg/day groups.