Record Display for the EPA National Library Catalog
RECORD NUMBER: 20 OF 117| Main Title | Carcinogen-DNA adducts : introduction, literature summary, and recommendations / | |||||||||||
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| Author | Soileau, S. D. | |||||||||||
| CORP Author | Lockheed Engineering and Management Services Co., Inc., Las Vegas, NV.;Environmental Monitoring Systems Lab., Research Triangle Park, NC. | |||||||||||
| Publisher | Environmental Monitoring Systems Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, | |||||||||||
| Year Published | 1987 | |||||||||||
| Report Number | EPA/600/4-87/005; EPA-68-03-3249 | |||||||||||
| Stock Number | PB87-145678 | |||||||||||
| Subjects | Carcinogens ; DNA | |||||||||||
| Additional Subjects | Carcinogens ; Deoxyribonucleic acids ; Risk ; Biological agents ; Proteins ; DNA ; Environmental monitoring ; Xenobiotics ; Proteins ; Environmental health ; Adducts | |||||||||||
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| Collation | vi, 126 pages ; 28 cm | |||||||||||
| Abstract | The report summarizes the literature concerning adducts formed by xenobiotics with DNA and/or protein and discusses their feasibility as a monitoring tool for use in exposure and risk assessment. The report is divided into three segments. The first segment provides an introduction to DNA damage and its relation to carcinogenesis. This segment also discusses available methodology for the measurement of macromolecular (DNA, protein) adducts. The techniques were evaluated according to their sensitivity, selectivity, limitations and future possibilities. The next segment provides a summary of the current literature on the individual chemicals found to form adducts in both man and experimental animals. The information in this segment was also tabulated and is located in the appendix. Finally, the conclusion and recommendation section discusses the overall potential for the use of macromolecular adducts as a measure of dose, given the current technology. |
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| Notes | "January 1987." "PB87-145678." "EPA/600/4-87/005." Includes bibliographical references (p. 100-126) Microfiche. 68-03-3249 |