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Main Title Low-level carbon monoxide exposure and work capacity at 1600 meters /
Author Weiser, Philip C.
Other Authors
Author Title of a Work
Morrill, Callis Gary.
Cropp, Gerd J. A.
Kurt, Thomas L.
Dickey, David W.
Morrill, Callis Gary, 1938-
Publisher U.S. Environmental Protection Agency, Health Effects Research Laboratory ; For sale by the National Technical Information Service,
Year Published 1979
Report Number EPA 600/1-79/037; EPA-68-02-2244
Stock Number PB80-129083
OCLC Number 37860229
Subjects Carbon monoxide--Physiological effect ; Work--Physiological aspects ; Respiration
Additional Subjects Carbon monoxide ; Exercise(Physiology) ; Air pollution ; Exposure ; Physiological effects ; Concentration(Composition) ; Performance(Human) ; Air pollution effects(Humans) ; Carboxyhemoglobin ; Environmental health
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD  EPA 600-1-79-037 Headquarters Library/Washington,DC 04/25/2014
EKBD  EPA-600/1-79-037 Research Triangle Park Library/RTP, NC 09/07/2001
ELBD ARCHIVE EPA 600-1-79-037 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
NTIS  PB80-129083 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation viii, 27 p. : tables ; 28 cm.
At sea level, low-level carbon monoxide (CO) exposure impairs exercise performance. To determine if altitude residence at 1600 m augments this CO effect, two studies of graded treadmill work capacity were done. The Initial Study investigated nine, non-smoking male subjects breathing either filtered air (FA) or 28 ppm CO in filtered air. End-exercise carboxyhemoglobin (HbCO) levels averaged 0.9 %HbCO breathing FA and 4.7 %HbCO breathing CO. Total work performance and aerobic work capacity were reduced. Work heart rate was elevated, and post-exercise left ventricular ejection time breathing CO did not shorten to the same degree as with FA exposure. CO exposure resulted in a lower anaerobic threshold, and a greater minute ventilation occurred at work rates heavier than the anaerobic threshold due to an increased blood lactate level. The Dose-Response Study exposed twelve subjects to FA or CO such that the end-exercise HbCO levels were 0.7, 3.5, 5.4 and 8.7 %HbCO. Exercise performance and aerobic work capacity were impaired in proportion to the CO exposure. In both studies, maximal cardio-pulmonary responses were not different, but submaximal exercise changes were elevated breathing CO. Thus, in healthy young men residing near 1600 m, an increase in low-level CO exposure produced a linear decrement in maximal aerobic performance similar to that reported at sea level.
Contract No. EPA 68-02-2244. "EPA-600/1-79-037." Project officer: Edward Haak. Includes bibliographical references (p. 25-26).