Abstract: Practical and informative guidance is provided to scientists and science students (with an emphasis on biology) to prepare well written manuscripts that have a high probability of becoming accepted for publication in technical journals. While journal requirements vary widely, basic writing and formating principles that are accepted in most science disciplines are presented. The material is expressly presented in a "how to" format for each category addressed. Individual chapters focus on the preparation of the manuscript title, author listing, abstract, individual text components (introduction, experimental, results, discussion), tables, illustrations and typing. Other topics address the submission, review, and publishing processes. The writing of reviews, conference reports, and theses also is discussed. Appendices are included on abbreviations and common style and spelling errors. (wz).