||Pargyline and gamma-Butyrolactone Enhance Tyrosine Hydroxylase Immunostaining of Nigrostriatal Axons.
Haykal-Coates, N. ;
O'Callaghan, J. P. ;
Reinhard, J. F. ;
Jensen, K. F. ;
||Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC. ;Wellcome Research Labs., Research Triangle Park, NC.
Tyrosine hydroxylase ;
Substantia nigra ;
Western blotting ;
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Administration of pargyline or gamma-butyrolactone enhanced immunostaining of tyrosine hydroxylase immunoreactive axons in the striatum. The qualitative characteristics of the enhancement were compound dependent and the enhancement was not associated with an increase in the amount of tyrosine hydroxylase within the striatum. These results demonstrate the pharmacological enhancement of immunostaining for neurotransmitter synthetic enzymes in the absence of increased synthesis. (Copyright (c) 1991 Elsevier Science Publishers B.V.)