This report is produced under the cosponsorship of the Colorado Department of Public Health, the Nebraska Department of Health, and the Wyoming Department of Public Health, and the U. S. Public Health Service. It is based on data gathered and reported in the South Platte River Basin Water Pollution Investigation Report of 1950 and subsequent information. The report also presents information concerning use of water resources, pollution entering water resources and resulting damages, benefits which may result from pollution prevention and abatement, pollution prevention measures in effect and those needed. Data and knowledge now available are sufficient to permit the immediate solution of most of the pollution problems within the South Platte River Basin without awaiting the results of additional surveys and studies. A sincere effort has been made to present a fair picture of the water pollution problems in the South Platte River Basin and to present reasonable conclusions and recommendations. (Author Modified Abstract)