"Reprinted from Environmental monitoring assessment, volume 53, no. 1, 1998." Includes bibliographical references.

Preface. -- Trends in concentrations and effects of persistent toxic contaminants in the Great Lakes: their significance for inferring cause-effect relationships and validating management actions. -- Designing the environmental reults workshop: historical context, causality and candidate species. -- Current status and temporal trends in concentrations of peristent toxic substances in sport fish and jeuvenile forage fish in the Canadian waters of the Great Lakes. -- Organochlorine contaminatns in herring gull eggs from the Great Lakes, 1974-1995: change point regression analysis and short-term regression. -- Reproductive and physiological effects of environmental contaminants in fish-eating birds of the Great Lakes: a review of historical trends. -- Monitoring the elimanation of persistent toxic subdstances from the Great Lakes: chemical and physiological evidence from adult herring gulls. -- Spatial and temporal trends in organochlorine contamination and bill deformities in double-crested cormorants (phalacrocorx auritus) from the Canadian Great Lakes. -- Trends of contaminants and effects in bald eagles of the Great Lakes Basin. -- Long term trends in liver neoplasm epizootics of brown bullhead in the Black River, Ohio. -- Reptiles and amphibians: shy and sensitive vertebrates of the Great Lakes Basin and St. Lawrence River. -- Human health effects of environmental pollutants: new insights.