Includes bibliographical references and index.

Executive summary. Organization and framework ; Toxicology summary ; Exposure assessment ; Conclusions about health outcomes ; Increased risk of disease among Vietnam veterans ; Observations and research recommendations -- Veterans and Agent Orange: previous IOM reports. Background ; Conclusions about health outcomes ; Increased risk of disease among Vietnam veterans ; Existence of a plausible biologic mechanism or other evidence of a causal relationship ; Research recommendations -- Toxicology ; Lay summary ; Overview of the scientific literature in Update 2000 ; Toxicity profile updates ; Issues in evaluating the evidence -- Methodological considerations in evaluating the evidence ; Questions to be addressed ; Issues in evaluating the evidence -- Exposure assessment. Occupational and environmental exposures to herbicides and dioxin ; Military use of herbicides in Vietnam ; Exposure assessment in studies of Vietnam veterans -- Epidemiologic studies. Occupational studies ; Environmental studies ; Vietnam veteran studies ; Observations and research recommendations -- Cancer. Gastrointestinal tract tumors ; Hepatobiliary cancers ; Nasal and nasopharyngeal cancer ; Laryngeal cancer ; Lung cancer ; Bone cancer ; Soft-tissue sarcomas ; Skin cancers: all types ; Skin cancer: melanoma ; Skin cancer: basal and squamous cell (nonmelanoma) ; Breast cancer ; Cancers of the female reproductive system ; Prostate cancer ; Testicular cancer ; Urinary bladder cancer ; Renal cancer ; Brain tumors ; Non-Hodgkin's lymphoma ; Hodgkin's Disease ; Multiple myeloma ; Leukemia -- Reproductive effects. Birth defects ; Fertility ; Spontaneous abortion ; Stillbirth, Neonatal death, and infant death ; Low birthweight and preterm birth ; Childhood cancers ; Sex ratio -- Neurobehavioral disorders. Cognitive and neuropsychiatric effects ; Motor/coordination dysfunction ; Chronic persistent peripheral neuropathy ; Acute and subacute transient peripheral neuropathy ; Conclusions for neurobehaviorial disorders -- Other health effects. Chloracne ; Porphyria cutanea tarda ; Respiratory disorders ; Immune system disorders ; Diabetes ; Lipid and lipoprotein disorders ; Gastrointestinal and digestive disease, Including liver toxicity ; Circulatory disorders ; Amyloidosis.