Record Display for the EPA National Library Catalog


Main Title Neural Factors in the Development of Renal Function: Effect of Neonatal Central Catecholaminergic Lesions with 6-Hydroxydopamine.
Author Gray, J. A. ; Kavlock, R. J. ; Seidler, F. J. ; Slotkin, T. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Duke Univ. Medical Center, Durham, NC. Dept. of Pharmacology.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/325;
Stock Number PB92-120492
Additional Subjects Vasopressin ; Kidney ; Catecholamines ; Peripheral nerves ; Body weight ; Homeostasis ; Rats ; Newborn animals ; Kidney concentrating ability ; Organ weight ; Water consumption ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB92-120492 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
Peripheral sympathetic neurons are thought to provide trophic regulatory signals for development of their target tissues. In the current study, the authors investigated the role of sympathetic tone in the functional development of the kidney in the rat, using intracisternal administration of 6-hydroxydopamine (6-OHDA). The treatment destroys central catecholaminergic pathways and permanently reduces sympathetic activity without ablating peripheral nerves terminals. Renal function was evaluated over the first two postnatal weeks, a period of rapid glomerular and tubular maturation, by tests of basal renal clearance, urinary concentrating ability in response to fluid deprivation, and the response to a vasopressin analog (DDAVP). Although basal renal clearance and the homeostatic response to fluid deprivation developed normally in the lesioned rats, the response to a maximally-effective dose of DDAVP was attenuated at the end of the second postnatal week, a time during which the normal response increased dramatically.