Abstract |
A data summary regarding Oleylamine is provided, including product chemistry, production and uses, occupational exposure, and toxicology. Oleylamine products manufactured by Akzo (under the registered trademarks, Armeen O, Armeen OD (distilled), and Armeen OL) are mixtures of primary, aliphatic amines of varying hydrocarbon chain lengths (C12-C18), with the most abundant molecule being oleylamine. Their primary uses are as additives in lubricating oils, greases, and to a lesser degree, gasoline. U.S. production is estimated at about 5 million pounds/year. Oleylamine is considered to be a skin and eye irritant. Workers are required to wear protective clothing on the job, and to follow specified protective procedures if skin or eyes are directly exposed. Toxicity data for several related compounds, cited from published sources, is presented, and indicates oleylamine may be irritating and corrosive to the skin (as seen in tests of tallow amine with rabbits). Levels of tallow amine several times higher than those of Armeen O found to be in the work atmosphere are not toxic to rats exposed by the inhalation route, and acute oral toxicity to rats is moderate (oral LD50 of tallow amine = 2000 mg/kg). The i.p. LD50 values for several related substances range from 250 to 1280 mg/kg. Oral tests for chronic, reproductive and teratogenic effects of related compounds with rats and mice have shown low-level toxicity, but no evidence of teratogenicity. |