||Initial Submission: Teratology Screen in Rats (c-180, C-181, C-182, C-236, C-253, C-254, C-255, C-256, C-257, C-258, C-259) (Final Report) with Attachments and Cover Letter.
||Hazleton Labs., Falls Church, VA.; Hoechst Celanese Corp., Summit, NJ.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Valeric Acid ;
Reproduction/fertility Effects ;
Toxic substances ;
Laboratory animals ;
CAS No 109-52-4
||Some EPA libraries have a fiche copy filed under the call number shown.
Valeric acid (C-180; 109-52-4) was evaluated for developmental effects in 22 female Crl:COBS, CD(SD)BR rats administered 750 mg/kg of the test substance by gavage on days 6 through 15 of gestation. A control group received corn oil. Maternal animals showed an increased incidence of clinical observations (specific signs not reported). Offspring showed an increased incidence of delayed ossification of several bone structures.