Record Display for the EPA National Library Catalog

RECORD NUMBER: 4 OF 5

OLS Field Name OLS Field Data
Main Title Initial Submission: Chronic Mouse Dermal Toxicity Study of a Mixture of Valeric Acid; Heptanoic Acid; Pelargonic Acid; and Tripropylene Glycol of Hexafluoroisopropanol in Guinea Pigs and Rats with Cover Letter dated 10/15/1992.
CORP Author Charles F. Kettering Research Lab., Yellow Springs, OH.; Rhone-Poulenc Ag Co., Research Triangle Park, NC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 8EHQ-1092-11669
Stock Number OTS0571597
Additional Subjects Toxicology ; Health effects ; Valeric acid ; Heptanoic acid ; Pelargonic acid ; Tripropylene ; Chronic toxicity ; Carcinogenicity ; Mammals ; Mice ; Dermal ; CAS No 109-52-4 ; CAS No 111-14-8 ; CAS No 112-05-0 ; CAS No 42978-66-5
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NTIS  OTS0571597 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 09/09/2010
Collation 105p
Abstract
Groups of 50 male mice received twice-weekly applications of 25 or 50 mg doses of a test material. C-181 induced four skin tumors in three mice when tested in 50 mg doses as a 75% solution in mineral oil. Both benign and malignant skin tumors were observed in 1750 mice treated with C-180 along with severe dermal and systemic toxicity. An 18% decrease in average body weight and a marked reduction in survival was observed with C-180. No skin tumors were observed with either C- 178 or C-182.