Record Display for the EPA National Library Catalog


Main Title Hexachlorobenzene-Induced Renal Maldevelopment in CD-1 Mice and CD Rats.
Author Andrews, J. E. ; Courtney, K. D. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/D-85/160;
Stock Number PB85-235976
Additional Subjects Urologic diseases ; Environmental surveys ; Ecology ; Toxicology ; Pregnancy complications ; Laboratory animals ; Rats ; Mice ; Ingestion(Biology) ; Concentration(Composition) ; Exposure ; Kidneys ; Hydronephrosis ; Dosage ; Foreign technology ; Benzene/hexachloro ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB85-235976 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 21p
Enlarged kidneys and hydronephroses were observed in day 15 postpartum (pp) CD-1 mouse pups from dams treated with 10 or 50 mg HCB/kg body weight on days 6-16 of gestation. Additional studies showed that enlarged kidneys occurred as well on days 1 and 20 pp. CD rat pups from dams exposed to 10 mg HCB/kg body weight on days 15-20 of gestation had enlarged kidneys on postpartum day but not on days 10 or 20. In the CD rat, there was a significant increase in the kidney-to-body-weight ratio and the liver-to-body-weight ratio for the HCB exposed pups at all three time periods. Pre- and post-natal exposure to HCB resulted in renal maldevelopment in CD-1 mice and CD rat in terms of enlarged kidneys and hydronephrosis.