Main Title |
Hexachlorobenzene-Induced Renal Maldevelopment in CD-1 Mice and CD Rats. |
Author |
Andrews, J. E. ;
Courtney, K. D. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1985 |
Report Number |
EPA/600/D-85/160; |
Stock Number |
PB85-235976 |
Additional Subjects |
Urologic diseases ;
Environmental surveys ;
Ecology ;
Toxicology ;
Pregnancy complications ;
Laboratory animals ;
Rats ;
Mice ;
Ingestion(Biology) ;
Concentration(Composition) ;
Exposure ;
Kidneys ;
Hydronephrosis ;
Dosage ;
Foreign technology ;
Benzene/hexachloro ;
Toxic substances
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB85-235976 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
21p |
Abstract |
Enlarged kidneys and hydronephroses were observed in day 15 postpartum (pp) CD-1 mouse pups from dams treated with 10 or 50 mg HCB/kg body weight on days 6-16 of gestation. Additional studies showed that enlarged kidneys occurred as well on days 1 and 20 pp. CD rat pups from dams exposed to 10 mg HCB/kg body weight on days 15-20 of gestation had enlarged kidneys on postpartum day but not on days 10 or 20. In the CD rat, there was a significant increase in the kidney-to-body-weight ratio and the liver-to-body-weight ratio for the HCB exposed pups at all three time periods. Pre- and post-natal exposure to HCB resulted in renal maldevelopment in CD-1 mice and CD rat in terms of enlarged kidneys and hydronephrosis. |