Record Display for the EPA National Library Catalog


Main Title Evaluation of Renal Function in Neonatal Rats.
Author Kavlock, Robert J. ; Gray, Jacqueline A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1982
Report Number EPA-600/J-81-169;
Stock Number PB83-209700
Additional Subjects Urologic diseases ; Renal failure ; Rats ; Laboratory animals ; Reprints ; Ontogenesis ; Neonatology
Library Call Number Additional Info Location Last
NTIS  PB83-209700 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
The ontogenetic profile of several parameters of neonatal renal development in the rat is presented. Nephrogenesis was observed to continue at a rapid pace between birth and 8 days of age and to be virtually complete by 11 days of age. The activity of alkaline phosphatase, a brush border enzyme, declined during this time period relative to organ growth as a whole. The ability to elaborate a concentrated urine when presented with a period of fluid deprivation was barely present at birth and increased dramatically with age. Finally, the diuresis response to an orally administered water load was detected on the second post-natal day, while the response to antidiuretic hormones was present to a slight degree on the first postnatal day.