Record Display for the EPA National Library Catalog


Main Title Cadmium as a Respiratory Toxicant.
Author Grose, E. C. ; Graham, J. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1987
Report Number EPA/600/D-87/020;
Stock Number PB87-146262
Additional Subjects Cadmium ; Toxic diseases ; Respiratory diseases ; Exposure ; Urologic diseases ; Malignant neoplasms ; Emphysema ; Occupational diseases ; Industrial hygiene ; Toxicology ; Health effects ; Epidemiological studies ; Environmental effects ; Environmental monitoring ; Animal inhalation studies ; Threshold limit value ; TLV(Threshold Limit Value)
Library Call Number Additional Info Location Last
NTIS  PB87-146262 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 28p
Cadmium is a major respiratory toxicant as evidenced by numerous human and animal studies. Controlled animal inhalation studies provide supporting evidence to the associations observed in epidemiological studies that Cd has the potential to cause lung fibrosis, emphysema, cancer, and kidney disease after prolonged exposure. Shorter-term exposure studies indicate that mechanisms thought to be involved in several of these chronic disease states (especially fibrosis and emphysema) are acutely activated. The evidence of toxicity is sufficiently clear that a TLV has been set and the International Agency for Research on Cancer has named Cd as a Group B1 substance (probable human carcinogen). The risk to Cd exposure is enhanced by its chemical and physical properties that result in bioaccumulation. Thus, even a low level exposure over long periods of time would be expected to reach doses that could be toxic.