| Abstract |
The Office of Program Integration and Infomation's Survey and Analysis Division is currently conducting a preliminary assessment of halogenated organic compounds in human and environmental media. This effort was undertaken in response to the detection and identification of numerous halogenated hydrocarbons in the environment, notably in drinking water supplies. Although detected levels have generally been low, several halocarbons have entered the environment at relatively high concentrations as a result of accidental spills or contamination of animal feed. The reporting of halogenated pesticides in human blood, serum, and adipose tissue further heightens concern over the potential health effects which may be associated with a halocarbon insult. The major thrust of this preliminary assessment is a comprehensive and systematic ahalysis of selected halocarbons in man and the environment being conducted under contract by the Research Triangle Institute (RTI). This schematic flow diagram illustrates the interlocking relationships between the environment and man and their potential association with the incidence of disease, specifically cancer. The three program levels in Figure 1 represent: (1) the demonstration for man of a halocarbon dosage through environmental exposure via routes such as air, water and food; (2) the demonstration of a body-burden in man through the examination of urine, breath, blood, and tissues for halogenated hydrocarbons; and (3) the demonstration of an association (i.e., a response) between body-burden and the incidence of cancer. |
