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Main Title Trimethoxysilane: Acute Vapor Inhalation Toxicity in Rats with Attachments and Cover Letter dated 05/13/88.
CORP Author Mellon Inst.-Union Carbide Corp., Export, PA. Bushy Run Research Center. ;Union Carbide Corp., Danbury, CT.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 19 May 1988
Year Published 1988
Report Number 8HEQ-0588-0347;
Stock Number OTS-0204852-2
Additional Subjects Vapors ; Inhalation ; Toxicity ; Rats ; Exposure(Physiology) ; Chemical analysis ; Residues ; Central nervous system ; Respiratory distress ; Clinical signs ; Eye ; Nose ; Mouth ; Lesions ; Laboratory animals ; Discoloration ; Liver ; Lung ; Trimethoxysilane ; Union Carbide Corporation ; Sprague-Dawley rats
Library Call Number Additional Info Location Last
NTIS  OTS-0204852-2 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 68p
The acute inhalation toxicity of trimethoxysilane was investigated using Sprague-Dawley rats. A series of inhalation exposures was conducted in which five animal/sex were exposed once to trimethoxysilane vapor by static (for 10 or 60 min) or dynamic (for 1 or 4 hr) generation methods and then observed for 14 days postexposure. Under static generation conditions, all animals died during or within 2 hours following exposure to a nearly-saturated vapor concentration of trimethoxysilane for either 10 or 60 min. During the 1-hr static exposure, the analytical concentration of trimethoysilane decreased, over a 22-min period from 60,000 to 3,000 ppm, while the concentration of methanol (a reaction product of trimethoxysilance and water vapor) rose to approximately 111,000 ppm. During the 10-min static exposure, trimethyoxy-silane concentration decreased from 56,000 to 47,000 ppm (methanol concentration increased to 69,000). Clinical signs observed on the day of exposure included central nervous system excitation (e.g., tremors) and respiratory difficulties. During the exposure, a white residue covering the eyes, nose, and mouth was observed. Gross lesions included a mottled red discoloration of the lungs, dark purpose discoloration of the liver, and clear fluid in the traches and thoracic cavity. Microscopic examination of the lungs of rats from the 10-min exposure group included congestion, edema, and fibrin formation. In some rats, there was exfoliation of the bronchiolar epithelial cells.