The study shows the relationship between the rate of orthokinetic flocculation and the hydrodynamic parameters describing the internal structure of turbulence in stirred reactors. Specifically, the study derives a theoretical expression for the frequency of collisions between particles suspended in a turbulent fluid, in which the particles are larger than the smallest scale of the turbulence; develops a working formula expressing the degree of flocculation obtained in a continuous flow system as a function of the hydrodynamic parameters and physical properties of the system; verifies experimentally the proposed theory through the simultaneous determination of flocculation performance and hydrodynamic characteristics; and develops design criteria and operational considerations for full scale treatment plants.