||Evaluation of Delayed Neurotoxicity and Dose-Response Relationships of Phosphate Esters in the Adult Hen Prepared by Monsanto Company with Cover Letter.
||Du Pont de Nemours (E.I.) and Co., Wilmington, DE. DuPont Environmental Remediation Services.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
||4 Feb 1983
Dose response relationships ;
Histological techniques ;
Oral intake ;
Dermal absorption ;
Laboratory animals ;
Aryl phosphates ;
Phosphoric acid ;
||Some EPA libraries have a fiche copy filed under the call number shown.
An oral multiple-dose technique in hens was developed to determine the neurotoxic potential of a series of triaryl-, trialkyl- and alkyl-aryl phosphates. This potential was estimated by observation of abnormal behavioral signs and always verified by histological examination. This procedure permits dose tritration of an active material to quantify dose-response relationships. Initial evaluation of a series of phosphates for neurotoxicity yielded 3 active materials: tricresyl-phosphate, cresyl-diphenyl phosphate and o-isopropylphenyl- diphenyl-phosphate. Subsequent titration of active materials demonstrated that their neurotoxic potential differed markedly.