Record Display for the EPA National Library Catalog

RECORD NUMBER: 2 OF 4

OLS Field Name OLS Field Data
Main Title Initial Submission: Toxicity Studies of Triphenyl Phosphite with Cover Letter dated 09/01/1992.
CORP Author Eastman Kodak Co., Rochester, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 8EHQ-0992-10567
Stock Number OTS0570901
Additional Subjects Toxicology ; Health effects ; Toxic substances ; Triphenyl phosphite ; Acute toxicity ; Mammals ; Rats ; Oral ; Gavage ; Mice ; Cats ; Primary dermal irritation ; Guinea pigs ; Primary dermal sensitization ; Primary eye irritation ; Rabbits ; CAS No 101-20-0
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NTIS  OTS0570901 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 05/27/2010
Collation 6p
Abstract
The report pertains to phosphorous acid, triphenyl ester (synonym: triphenyl phosphite) (CAS No. 101-02-0) and is being submitted because of lethality with central nervous system signs observed in an acute intraperitoneal study in cats, decreased cholinesterase activity observed in an acute intraperitoneal toxicity study in mice, and effects observed in a dermal sensitization study in guinea pigs. The intraperitoneal LD, was less than 100 mg/kg in cats. Intraperitoneal injection of 100 mg/kg and 1,000 mg/kg in mice decreased cholinesterase levels by 20 and 43%, respectively. Abnormalities observed during a dermal sensitization study in guinea pigs included bruising of the skin from touching or handling, suggesting cataneous capillary fragility. The report is being identified as a study involving other than human effects (Unit II.B.2.b of CAP Agreement).